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KMID : 0381120150370110959
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Genes and Genomics
2015 Volume.37 No. 11 p.959 ~ p.968
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Complete genome sequence and comparative genome analysis of Streptococcus parauberis KCTC11980
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Seo Jung-Soo
Kwon Mun-Gyeong
Hwang Jee-Youn
Jung Sung-Hee
Han Hyun-Ja
Kim Myoung-Sug
Do Jeong-Wan
Park Myoung-Ae
Kim Dong-Wook
Cho Wang-Sik
Lee Kyung-Hoon
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Abstract
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Streptococcus parauberis is recognized as an alpha-hemolytic gram-positive bacterial pathogen associated with bovine udder mastitis. Recently, S. parauberis was identified as the major pathogen of olive flounder (Paralichthys olivaceus) streptococcosis in Northeast Asia, a disease that causes severe economic losses by triggering massive olive flounder mortality. In this study, the complete genome sequence of S. parauberis KCTC11980 was determined and analyzed. S. parauberis KCTC11980 harbors a single chromosome of 2,179,251 bp containing 2281 predicted coding sequences and featuring an average G+C content of 35.65 %. Dot-plot analysis of the entire genomic sequence and phylogenetic analysis of the 16S rRNA gene revealed a close evolutionary relationship between S. parauberis KCTC11980 and S. uberis. Our findings could serve as a basis for understanding the pathogen-host relationship and developing new prophylactic and therapeutic strategies against fish streptococcosis. This study also enhances our understanding of the physiology and evolution of a key representative of the Streptococcaceae family.
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KEYWORD
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Streptococcus parauberis, Genome sequence, Fish pathogen, Olive flounder, Paralichthys olivaceus, 16S rRNA
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